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DARK Classics in Chemical Neuroscience: Cathinone-Derived Psychostimulants

Cathinone is a plant alkaloid found in khat leaves of perennial shrubs grown in East Africa. Similar to cocaine, cathinone elicits psychostimulant effects which are in part attributed to its amphetamine-like structure. Around 2010, home laboratories began altering the parent structure of cathinone to synthesize derivatives with mechanisms of action, potencies, and pharmacokinetics permitting high abuse potential and toxicity. Read more

NIDA: Synthetic cathinones

You can download the brochure of the National Institute on Drug Abuse (USA) at THIS LINK.

Acute Pharmacological Effects of Oral and Intranasal Mephedrone: An Observational Study in Humans

You can read this open access article in English at THIS LINK. Read more

Synthetic cathinones

One of the predominant structural groups of NPS are synthetic cathinones. These are β-keto phenethylamines, that have similarities to amphetamine, methamphetamine and MDMA in structure and mechanism of action. Read more